Details of driver genes investigated

Driver geneEntrez IDFull nameSynonymsAlterations ConsideredStudiesTissuesTargets
ACVR2A 92 activin A receptor type 2A ACVR2 | ACTRII Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 4731
AFDN 4301 afadin, adherens junction formation factor MLLT4 | AF-6 | AF6 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 2 1916
AFF4 27125 AF4/FMR2 family member 4 MCEF | AF5Q31 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 3224
AKT2 208 AKT serine/threonine kinase 2 Amplifications or recurrent mutations 2 2 1087
APC 324 APC, WNT signaling pathway regulator DP3 | DP2.5 | PPP1R46 | DP2 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 3 3631
ARID1A 8289 AT-rich interaction domain 1A SMARCF1 | BAF250a | C10rf4 | B120 | C1orf4 | P270 | BAF250 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 6 8 8401
ARID1B 57492 AT-rich interaction domain 1B 6A3-5 | p250R | BAF250b | KIAA1235 | DAN15 | ELD/OSA1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 4 2 3020
ARID2 196528 AT-rich interaction domain 2 DKFZp686G052 | BAF200 | KIAA1557 | FLJ30619 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 3 2979
ASXL1 171023 additional sex combs like 1, transcriptional regulator KIAA0978 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 2956
ATM 472 ATM serine/threonine kinase ATC | ATDC | TELO1 | ATD | TEL1 | ATA Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 1 2023
ATRX 546 ATRX, chromatin remodeler RAD54 | XNP | MRX52 | JMS | XH2 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 2973
AXIN1 8312 axin 1 PPP1R49 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 1 676
B2M 567 beta-2-microglobulin Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 4086
BCOR 54880 BCL6 corepressor FLJ20285 | KIAA1575 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 3 3244
BIRC3 330 baculoviral IAP repeat containing 3 cIAP2 | MIHC | c-IAP2 | RNF49 | API2 | MALT2 | hiap-1 Amplifications or recurrent mutations 2 1 1215
BRAF 673 B-Raf proto-oncogene, serine/threonine kinase BRAF1 Recurrent mutations 3 4 5440
BRCA1 672 BRCA1, DNA repair associated FANCS | RNF53 | BRCC1 | PPP1R53 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 4 2 3509
BRCA2 675 BRCA2, DNA repair associated FANCD | FAD1 | BRCC2 | FANCD1 | XRCC11 | FAD | FACD Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 4 3 5229
CASP8 841 caspase 8 Casp-8 | MCH5 | MACH | FLICE Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 1 2196
CCND1 595 cyclin D1 PRAD1 | BCL1 | U21B31 | D11S287E Amplifications or recurrent mutations 5 4 5154
CCNE1 898 cyclin E1 CCNE Amplifications or recurrent mutations 3 3 2322
CDH1 999 cadherin 1 uvomorulin | UVO | CD324 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 5 2 4226
CDK4 1019 cyclin dependent kinase 4 PSK-J3 Amplifications or recurrent mutations 3 2 2678
CDKN2A 1029 cyclin dependent kinase inhibitor 2A CDK4I | INK4 | ARF | CMM2 | MTS1 | p19Arf | p19 | MLM | CDKN2 | p16INK4a | INK4a | p16 | p14 | p14ARF Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 7 12 10976
CDKN2C 1031 cyclin dependent kinase inhibitor 2C p18 | INK4C Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 3 2622
CIC 23152 capicua transcriptional repressor KIAA0306 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 2 1119
CREBBP 1387 CREB binding protein CBP | RSTS | KAT3A | RTS Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 3 3127
CTCF 10664 CCCTC-binding factor Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 3749
CTNNB1 1499 catenin beta 1 beta-catenin | CTNNB | armadillo Amplifications or recurrent mutations 3 3 4843
DNMT3A 1788 DNA methyltransferase 3 alpha Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 458
EGFR 1956 epidermal growth factor receptor ERBB1 | ERBB Amplifications or recurrent mutations 4 4 4449
EP300 2033 E1A binding protein p300 p300 | KAT3B Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 4 5 5323
ERBB2 2064 erb-b2 receptor tyrosine kinase 2 NEU | NGL | HER-2 | CD340 | HER2 Amplifications 6 3 5834
ERCC5 2073 ERCC excision repair 5, endonuclease XPGC | ERCM2 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 278
EZH2 2146 enhancer of zeste 2 polycomb repressive complex 2 subunit ENX-1 | EZH1 | KMT6 | KMT6A Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 4112
FANCA 2175 Fanconi anemia complementation group A FANCH | FAA | FA-H | FACA | FAH Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 3007
FAT1 2195 FAT atypical cadherin 1 CDHR8 | CDHF7 | FAT Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 2704
FBXW7 55294 F-box and WD repeat domain containing 7 SEL-10 | CDC4 | AGO | FBW7 | FBXW6 | FLJ11071 | SEL10 | FBX30 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 3681
FGFR1 2260 fibroblast growth factor receptor 1 FLT2 | BFGFR | KAL2 | N-SAM | H5 | H4 | CD331 | H2 | H3 | CEK | FLG Amplifications or recurrent mutations 1 1 991
FGFR2 2263 fibroblast growth factor receptor 2 CFD1 | K-SAM | TK14 | TK25 | JWS | KGFR | BEK | CEK3 | ECT1 | CD332 Amplifications or recurrent mutations 2 1 917
FLCN 201163 folliculin MGC17998 | BHD | MGC23445 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 1 2870
GNAS 2778 GNAS complex locus GNASXL | SgVI | SCG6 | GPSA | NESP | GNAS1 | NESP55 Amplifications or recurrent mutations 4 3 3139
HEY1 23462 hes related family bHLH transcription factor with YRPW motif 1 bHLHb31 | HESR1 | CHF2 | HERP2 | CHF-2 | HRT-1 | HESR-1 Amplifications or recurrent mutations 1 1 643
HNF1A 6927 HNF1 homeobox A HNF1 | TCF1 | MODY3 | LFB1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 176
HRAS 3265 HRas proto-oncogene, GTPase HRAS1 Recurrent mutations 1 1 668
IL7R 3575 interleukin 7 receptor CD127 Amplifications or recurrent mutations 3 2 3131
JAK2 3717 Janus kinase 2 JTK10 Amplifications or recurrent mutations 1 1 648
KDM5C 8242 lysine demethylase 5C DXS1272E | MRX13 | JARID1C | SMCX | XE169 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 428
KDM6A 7403 lysine demethylase 6A UTX Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 4 2706
KIT 3815 KIT proto-oncogene receptor tyrosine kinase C-Kit | SCFR | CD117 | PBT Amplifications or recurrent mutations 1 1 646
KRAS 3845 KRAS proto-oncogene, GTPase KRAS1 | KRAS2 Recurrent mutations 5 5 6548
MAP2K4 6416 mitogen-activated protein kinase kinase 4 MKK4 | SERK1 | MEK4 | PRKMK4 | JNKK1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 5 3 4229
MDM2 4193 MDM2 proto-oncogene HDM2 | MGC5370 Amplifications or recurrent mutations 2 1 1013
MET 4233 MET proto-oncogene, receptor tyrosine kinase DFNB97 | RCCP2 | HGFR Amplifications or recurrent mutations 3 2 2307
MLH1 4292 mutL homolog 1 HNPCC2 | FCC2 | HNPCC | COCA2 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 1 793
MSH2 4436 mutS homolog 2 HNPCC1 | COCA1 | HNPCC Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 2 855
MSH6 2956 mutS homolog 6 GTBP Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 3 4688
MYC 4609 MYC proto-oncogene, bHLH transcription factor MYCC | bHLHe39 | c-Myc Amplifications 5 6 6955
MYCN 4613 MYCN proto-oncogene, bHLH transcription factor N-myc | NMYC | bHLHe37 | MYCNOT Amplifications 2 1 2870
NBN 4683 nibrin AT-V2 | ATV | NBS1 | AT-V1 | NBS Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 602
NCOA3 8202 nuclear receptor coactivator 3 KAT13B | AIB1 | p/CIP | SRC3 | bHLHe42 | ACTR | CAGH16 | TNRC16 | TRAM-1 | SRC-3 | RAC3 Amplifications or recurrent mutations 2 2 1216
NCOR1 9611 nuclear receptor corepressor 1 TRAC1 | PPP1R109 | hN-CoR | hCIT529I10 | KIAA1047 | N-CoR | MGC104216 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 2858
NCOR2 9612 nuclear receptor corepressor 2 SMRT | SMRTE | TRAC-1 | TNRC14 | CTG26 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 1 1584
NF1 4763 neurofibromin 1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 5 6 6234
NF2 4771 neurofibromin 2 merlin | ACN | BANF | SCH Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 3288
NOTCH1 4851 notch 1 TAN1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 2 1867
NOTCH2 4853 notch 2 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 404
NRAS 4893 NRAS proto-oncogene, GTPase N-ras Recurrent mutations 4 5 6434
NSD1 64324 nuclear receptor binding SET domain protein 1 STO | KMT3B | FLJ22263 | ARA267 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 1 2055
NUP98 4928 nucleoporin 98 NUP96 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 2 686
PBRM1 55193 polybromo 1 PB1 | BAF180 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 3 2220
PIK3CA 5290 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PI3K Amplifications or recurrent mutations 6 7 8475
PIK3R1 5295 phosphoinositide-3-kinase regulatory subunit 1 GRB1 | p85 | p85-ALPHA Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 3 3533
PMS1 5378 PMS1 homolog 1, mismatch repair system component PMSL1 | MLH2 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 677
PPM1D 8493 protein phosphatase, Mg2+/Mn2+ dependent 1D Wip1 | PP2C-DELTA Amplifications or recurrent mutations 3 1 1873
PSIP1 11168 PC4 and SFRS1 interacting protein 1 DFS70 | p52 | LEDGF | p75 | PSIP2 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 1 1297
PTCH1 5727 patched 1 BCNS | NBCCS | PTCH Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 2 1503
PTEN 5728 phosphatase and tensin homolog MHAM | PTEN1 | TEP1 | BZS | MMAC1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 6 8 8506
PTPRK 5796 protein tyrosine phosphatase, receptor type K R-PTP-kappa Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 2 1521
RB1 5925 RB transcriptional corepressor 1 OSRC | PPP1R130 | RB Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 5 6 5921
RNF43 54894 ring finger protein 43 URCC | DKFZp781H0392 | FLJ20315 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 4 3 5052
RPL22 6146 ribosomal protein L22 EAP | L22 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 3 5715
SETD2 29072 SET domain containing 2 FLJ23184 | HIF-1 | KMT3A | KIAA1732 | HYPB Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 3 2068
SKP2 6502 S-phase kinase associated protein 2 FBXL1 | p45 | FBL1 Amplifications or recurrent mutations 4 3 4053
SMAD4 4089 SMAD family member 4 DPC4 | MADH4 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 5 7 5855
SMARCA4 6597 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 hSNF2b | BRG1 | FLJ39786 | SWI2 | SNF2-BETA | SNF2LB | SNF2L4 | BAF190 | SNF2 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 4 4 3869
SMARCB1 6598 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Snr1 | PPP1R144 | Ini1 | BAF47 | hSNFS | SNF5L1 | Sfh1p | RDT Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 483
SOX2 6657 SRY-box 2 Amplifications or recurrent mutations 1 2 966
SOX9 6662 SRY-box 9 CMPD1 | SRA1 | CMD1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 2 1970
SPOP 8405 speckle type BTB/POZ protein BTBD32 | TEF2 Amplifications or recurrent mutations 2 2 1842
STAG2 10735 stromal antigen 2 SA-2 | SCC3B | SA2 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 1415
STK11 6794 serine/threonine kinase 11 PJS | LKB1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 4 2 4508
TCF12 6938 transcription factor 12 HEB | HTF4 | HsT17266 | bHLHb20 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 403
TERT 7015 telomerase reverse transcriptase TRT | hEST2 | TCS1 | TP2 | EST2 Amplifications or recurrent mutations 3 2 2971
TET2 54790 tet methylcytosine dioxygenase 2 FLJ20032 | KIAA1546 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 567
TGFBR2 7048 transforming growth factor beta receptor 2 MFS2 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 2 735
THRAP3 9967 thyroid hormone receptor associated protein 3 BCLAF2 | TRAP150 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 551
TP53 7157 tumor protein p53 p53 | LFS1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 7 13 11384
TRRAP 8295 transformation/transcription domain associated protein Tra1 | PAF400 | TR-AP Amplifications or recurrent mutations 2 1 1242
TSC1 7248 TSC complex subunit 1 LAM | TSC | hamartin | KIAA0243 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 282
UBR5 51366 ubiquitin protein ligase E3 component n-recognin 5 DD5 | KIAA0896 | HYD | EDD | EDD1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 4179
VHL 7428 von Hippel-Lindau tumor suppressor VHL1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 2 1211