Studies included in this database:
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CancerGD: analysis of genetic dependencies in cancer |
Studies included in this database:
Link | PubMed ID | Title: | Authors | Experiment type | Journal | Drivers | Tissues | Targets |
---|---|---|---|---|---|---|---|---|
Marcotte(2012) | 22585861 | Essential gene profiles in breast, pancreatic, and ovarian cancer cells. | Marcotte R, Brown KR, Suarez F et al | shRNA | Cancer Discovery | 11 | 2 | 16028 |
Marcotte(2016) | 26771497 | Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance. | Marcotte R, Sayad A, Brown KR, et al | shRNA | Cell | 21 | 1 | 15697 |
Campbell(2016) | 26947069 | Large Scale Profiling of Kinase Dependencies in Cancer Cell Line | Campbell J, Ryan CJ, Brough R, et al | siRNA | Cell Reports | 18 | 6 | 714 |
Wang(2017) | 28162770 | Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras | Wang T, Yu H, Hughes NW, Liu B et al | CRISPR | Cell | 5 | 1 | 18664 |
Tsherniak(2017) | 28753430 | Defining a Cancer Dependency Map. | Tsherniak A, Vazquez F, Montgo et al | shRNA | Cell | 89 | 11 | 17098 |
McDonald(2017) | 28753431 | Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening | McDonald ER 3rd, de Weck A, Sc et al | shRNA | Cell | 84 | 12 | 7837 |
Meyers(2017) | 29083409 | Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. | Meyers RM, Bryan JG, McFarland et al | CRISPR | Nat Genet | 63 | 10 | 17671 |